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In this chapter, emerging post-quantum cryptographic (PQC) technologies are explored with a focus on lattice and code-based schemes, detailing how Physical Unclonable Functions (PUFs) can be integrated to generate secure public–private key pairs for future PKIs. Experimental evaluations demonstrate that, with proper optimization (e.g., using AVX2 and GPU acceleration), PQC protocols like CRYSTALS-Dilithium and LightSABER can achieve performance competitive with current ECC-based systems, paving the way for secure key distribution in the quantum era.